NI-42 是一种用于 BRPF 的结构正交化学探针，是有偏向性的BRPFs溴结构域 (BRD)抑制剂，BRPF1、2和3的IC50为7.9、48和260 nM; BRPF1、2和3的Kd值为40、210和940 nM，与非分类 IV BRD 蛋白相比具有很好的选择性。

NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent selectivity over nonclass IV BRD proteins.

NI-42 displays IC50s of 82, 310, and 4500 nM for BRD7, BRD9, and BRD4 (BD1), respectively. It has a Kd of 1130 nM for BRD9.

1884640-99-6

C18H15N3O3S

353.4

DMSO:95 mg/mL (268.82mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years