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MI-773
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1303607-07-9
包装与价格:
包装价格(元)
100 mg电议
200 mg电议

产品介绍
MI-773 是一种有效的Mdm2-p53蛋白质相互作用 (PPI) 抑制剂,对 Mdm2 具体高结合亲和力 (Kd=8.2 nM)。MI-773 具有抗肿瘤活性。

产品描述

MI-773 is a potent MDM2-p53 protein‐protein interaction (PPI) inhibitor with high binding affinity against MDM2 (K d =8.2 nM). MI-773 has antitumor activity [1] [2].

体外活性

SAR405838 (MI-77301), an analog of MI-773, displays 10 times higher binding affinity against MDM2 than MI-773 (K d =62 vs 8.2 nM). The antitumor activity of MI-77301 is more pronounced in a set of wild type p53 xenograft models than MI-773, including SJSA-1 osteosarcoma, human prostate, melanoma, colorectal tumor, LNCAP human prostate tumor and human acute lymphoblastic leukemia [1].

Cas No.

1303607-07-9

分子式

C29H34Cl2FN3O3

分子量

562.5

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years