BCH001 是喹啉衍生物，是一种选择性PAPD5抑制剂。它可以恢复先天性角化病诱导的多能干细胞中的端粒酶活性和端粒长度。它对聚 (A)-特异性核糖核酸酶或几种其他多核苷酸聚合酶均无抑制作用。它可用于调控衰老。

BCH001 is a specific small-molecule inhibitor of PAPD5.

BCH001, a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem cells.?When human blood stem cells engineered to carry DC-causing PARN mutations were xenotransplanted into immunodeficient mice, oral treatment with a repurposed PAPD5 inhibitor, the dihydroquinolizinone RG7834, rescued TERC 3' end maturation and telomere length.?

384859-58-9

C20H15F3N2O5

420.34

DMSO:84 mg/mL (199.84 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years