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17-phenyl trinor Prostaglandin E2 ethyl amide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
17-phenyl trinor Prostaglandin E2 ethyl amide图片
CAS NO:1219032-20-8
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议

产品介绍

产品描述

17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 μM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters. Modification of the C-1 carboxyl group to an ethyl amide serves to increase lipid solubility, thereby improving uptake into tissues and further lowering the effective concentration. Ethyl amide groups are then removed by amidases, regenerating the active free acid.

Cas No.

1219032-20-8

分子式

C25H35NO4

分子量

413.55

别名

17-phenyl trinor Prostaglandin E2 ethyl amide

储存和溶解度

PBS (pH 7.2):0.5 mg/mL
DMSO:100 mg/mL
Ethanol:100 mg/mL
DMF:100 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years