您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Adenosine Dialdehyde(ADOX)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Adenosine Dialdehyde(ADOX)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Adenosine Dialdehyde(ADOX)图片
CAS NO:34240-05-6
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
Adenosine, periodate oxidized
腺苷二醛
Adenosinedialdehyde
Adenox
Periodate-oxidized adenosine
产品介绍
Adenosine Dialdehyde 是嘌呤核苷类似物,是S-腺苷高半胱氨酸水解酶(SAHH)的有效抑制剂(Ki=3.3nM)。Adenosine Dialdehyde 在体内具有较强的抗肿瘤活性。

产品描述

Adenosine dialdehyde is a purine nucleoside analogue. Adenosine dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.

体外活性

Adenosine dialdehyde suppresses MNB cell replication in tissue culture (1.5 μM, 50% inhibition) [1].

体内活性

Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice. Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals. Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity[2].

Cas No.

34240-05-6

分子式

C10H11N5O4

分子量

265.225

别名

Adenosine, periodate oxidized;腺苷二醛;Adenosinedialdehyde;Adenox;Periodate-oxidized adenosine

储存和溶解度

DMSO:9 mg/mL (33.9 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years