Adenosine Dialdehyde 是嘌呤核苷类似物,是S-腺苷高半胱氨酸水解酶(SAHH)的有效抑制剂(Ki=3.3nM)。Adenosine Dialdehyde 在体内具有较强的抗肿瘤活性。
产品描述
Adenosine dialdehyde is a purine nucleoside analogue. Adenosine dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.
体外活性
Adenosine dialdehyde suppresses MNB cell replication in tissue culture (1.5 μM, 50% inhibition) [1].
体内活性
Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice. Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals. Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity[2].
Cas No.
34240-05-6
分子式
C10H11N5O4
分子量
265.225
别名
Adenosine, periodate oxidized;腺苷二醛;Adenosinedialdehyde;Adenox;Periodate-oxidized adenosine
储存和溶解度
DMSO:9 mg/mL (33.9 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years