S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ameliorated memory impairment induced by cholinergic deficit in the water maze paradigm of Wistar rats. S-8510 augmented LTP of the Schaffer collateral/commissural fiber-CA1 synapses in the hippocampal slice preparations of SD rat. S-8510 increased the extracellular levels of acetylcholine and noradrenaline in the hippocampus of Wistar rat.

151224-83-8

C12H10N4O2

242.23

S-8510;SB737552;SB 737552;S8510;SB-737552;S 8510

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years