您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > ALK5-IN-9
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
ALK5-IN-9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2489611-06-3
包装与价格:
包装价格(元)
5 mg电议
50 mg电议
100 mg电议

产品介绍
ALK5-IN-9 (Compound 8h) 是一种有效并具有口服活性的TGFβRI(ALK5) 抑制剂。ALK5-IN-9 抑制 ALK5 自磷酸化和 NIH3T3 细胞活性,IC50值分别为 25 nM 和 74.6 nM。ALK5-IN-9 还显示出良好的药代动力学特征并改善了 hERG 抑制。ALK5-IN-9具有研究癌症疾病的潜力。

产品描述

ALK5-IN-9 (Compound 8h) is a potent and orally active inhibitor of TGFβRI ( ALK5 ). ALK5-IN-9 inhibits ALK5 autophosphorylation and NIH3T3 cell activity with IC 50 values of 25 nM and 74.6 nM, respectively. ALK5-IN-9 also shows favorable pharmacokinetic profile and ameliorated hERG inhibition. ALK5-IN-9 has the potential for the research of cancer disease [1].

Cas No.

2489611-06-3

分子式

C29H35F3N6O3

分子量

572.62

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years