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Sulfosuccinimidyl oleate sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sulfosuccinimidyl oleate sodium图片
CAS NO:1212012-37-7
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
Sulfo-N-succinimidyl oleate sodium
产品介绍
Sulfosuccinimidyl oleate sodium 是一种长链脂肪酸。它可以抑制脂肪酸转运到细胞中。它具有抗炎作用。

产品描述

Sulfosuccinimidyl oleate sodium is a long-chain fatty acid that inhibits the transport of fatty acids to cells. Sulfosuccinimidyl oleate sodium is an effective, irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to CD36 receptors on the surface of microglia.

体外活性

Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1].

体内活性

In male BALB/cABom mice with pMCAo model, Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls. In addition, Sulfosuccinimidyl oleate(50 mg/kg) is suitable to see a beneficial effect after stroke[1].

Cas No.

1212012-37-7

分子式

C22H36NNaO7S

分子量

481.58

别名

Sulfo-N-succinimidyl oleate sodium

储存和溶解度

DMSO:60 mg/mL (124.59 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years