HQ461 是一种分子胶，可促进 CDK12-DDB1 相互作用并触发cyclin K降解， cyclin K 的降解会损害 CDK12 的功能，导致 CDK12 底物磷酸化降低、DNA 损伤反应基因下调和细胞死亡。

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.

1226443-41-9

C15H15N5OS2

345.44

DMSO:62 mg/mL (179.48 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years