5-Chloro-2'-deoxyuridine 是胸腺嘧啶的类似物,可用于次氯酸对 DNA 和 DNA 前体的破坏作用的研究。
产品描述
5-Chloro-2'-deoxyuridine is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors.
体外活性
The mammalian cells incorporate the analog into DNA when 5-Chloro-2’-deoxyuridine (ClDU) is placed into the tissue culture medium. It is observed that a 10 μM concentration of 5-Chloro-2’-deoxyuridine in the media does not alter cell division kinetics. Previously it has been shown that 5-Chloro-2’-deoxyuridine is metabolized and incorporated into DNA using antibodies that bind selectively to DNA containing halogenated bases. In this study, 5-Chloro-2’-deoxyuridine is more similar to BrdU in acting as a T analog. The toxicity of 5-Chloro-2’-deoxyuridine could in part be attributed to inhibition of thymidylate synthase [1].
Cas No.
50-90-8
分子式
C9H11ClN2O5
分子量
262.65
别名
5-Chlorodeoxyuridine;CldU;5-氯-2-脱氧尿嘧啶核苷
储存和溶解度
DMSO:125 mg/mL (475.92 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years