Troxipide 是非分泌型胃保护剂，是口服具有活力的胃炎和胃溃疡的防御因子的增强剂，具有抗溃疡、抗炎和粘液分泌作用。

Troxipide, a new-type systemic non-antisecretory gastric cytoprotective agent, which is mucus-secreting, anti-ulcer, and anti-inflammatory properties irrespective of pH of stomach or duodenum.

Troxipide is a new-type anti-ulcer compound that has an inhibitory effect on human neutrophil migration and has various agonist-induced activation. It inhibits neutrophil-mediated inflammation and oxidative stress but does not improve gastric mucus composition and output. In addition, it can increase the secretion of the prostaglandin, a cytoprotective agent.

Gastric mucosal metabolism and blood flow will be enhanced by Troxipide.

Surface Plasmon Resonance (SPR) studies: The binding experiments are carried out on a ProteOn XPR36 biosensor at 25°C using the HTE sensor chip. The flow cells of the sensor chip are loaded with a nickel solution at 30 μL/min for 120 s to saturate the Tris–NTA surface with Ni(II) ions. Purified His-tagged STAT3 and STAT5 in PBST buffer (PBS with 0.005% (v/v) Tween-20 and 0.001% DMSO pH 7.4) is injected in the first and second channels of the chip respectively in the vertical direction at a flow rate of 25 μg/μL for 300 s, which attained, on average, ~8000 resonance unit (RU). After a wash with PBST buffer, inhibitors binding to the immobilized proteins is monitored by injecting a range of concentrations along with a blank at a flow rate of 100 μL/min for 200 s for each of these small molecules. When the injection of the small molecule inhibitor is completed, running buffer is allowed to flow over the immobilized substrates for the non-specifically bound inhibitors to dissociate for 600 s. Following dissociation of the inhibitors, the chip surface is regenerated with an injection of 1 M NaCl at a flow rate of 100 μL/ml for 18 s. Interspot channel reference is used for non-specific binding corrections and the blank channel used with each analyte injection served as a double reference to correct for possible baseline drift. Data are analyzed using ProteOn Manager Software version 3.1. The Langmuir 1:1 binding model was used to determine the KD values.

30751-05-4

C15H22N2O4

294.35

曲昔派特;曲昔匹特;Aplace

DMSO:15 mg/mL (51 mM)
Ethanol:3 mg/mL (10.19 mM)
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years