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Methylproamine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Methylproamine图片
CAS NO:188247-01-0
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Methylproamine是一种与DNA结合的辐射保护剂,可以修复辐射诱导的短暂活性氧。

产品描述

Methylproamine is a DNA-binding radioprotector , acts by repair of transient radiation-induced oxidative species on DNA.

体外活性

Immunocytochemical methods were used to measure the accumulation of phosphorylated H2AX (γH2AX) foci following ionizing radiation (IR) in patient-derived lymphoblastoid cells exposed to methylproamine. Pulsed field gel electrophoresis DNA damage and repair assays were performed to directly interrogate the action of methylproamine on DNA in irradiated cells.Methylproamine-treated cells had fewer γH2AX foci after IR compared to untreated cells. Also, the presence of methylproamine decreased the amount of lower molecular weight DNA entering the gel[2].

Cas No.

188247-01-0

分子式

C28H31N7

分子量

465.59

储存和溶解度

DMSO:41 mg/mL (88.06 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years