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Fulvene-5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fulvene-5图片
CAS NO:1075723-01-1
包装:5 mg
市场价:9850元

产品介绍

产品描述

Fulvene-5 has antitumor activity.Fulvene-5 is a potent NADPH oxidase 4 (NOX4) inhibitor with antioxidant properties. Fulvene-5 is a reactive oxygen species (ROS) modifying agent and a potent radioprotector.

体外活性

Fulvene-5 (0.5-1.0 μM) treatment decreases the expression of Ang2, delta-like ligand 4 (DLL4), placental growth factor (PLGF), and Nrarp in a dose-dependent manner in bEnd.3 cells.Fulvene-5 (10?μM; 1 hour) facilitates the reversal of HCT116 TP53 wild type (WT) and HCT116 isogenic TP53 null mutant (Mut) cell cultures adaptive responses from pro-survival to radio-sensitization and vice versa. These changes are accompanied by corresponding reversals in the translocation of survivin to the nuclei of TP53 WT and to the cytoplasm of TP53 Mut cells. The potential role of NOX4 in the expression of the survivin-associated adaptive response is investigated by transfecting HCT116 cells with NOX4 siRNA oligomers to inhibit NOX4 expression. Under these conditions NOX4 expression is inhibited by about 50%.

体内活性

Fulvene-5??treatment potently inhibits hemangioma growth in mice.

Cas No.

1075723-01-1

分子式

C26H18N2

分子量

358.43

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years