Thiocolchicine 是一种有效的微管蛋白聚合抑制剂，IC50 为 2.5 μM，Ki 为 0.7 μM。 Thiocolchicine 诱导细胞凋亡。 Thiocolchicine 可用作 ADC 技术中的 ADC 细胞毒素。

Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 μM and a Ki of 0.7 μM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.

Thiocolchicine (1 nM-100 μM; 24-72 hours) shows a relationship between cell cycle blocking activity and growth inhibition in breast cancer cells. Thiocolchicine inhibits cell proliferation of MDA-MB-231 and multidrug-resistant (MDR) MCF-7 ADRr breast cancer cells with IC50s of 0.6 nM and 400 nM, respectively, as well as MDR CEM-VBL leukemia cells with an IC50 of 50 nM[1]. Thiocolchicine is against MCF-7, LoVo, LoVo/DX, A-549 and BALB/3T3 cells with IC50 values of 0.01 μM, 0.021 μM, 0.398 μM, 0.011 μM and 0.114 μM, respectively[2].

2730-71-4

C22H25NO5S

415.5

DMSO:95 mg/mL (228.64 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years