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PGPC
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PGPC图片
CAS NO:89947-79-5
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议

产品名称
1-Palmitoyl-2-glutaryl phosphatidylcholine
产品介绍

产品描述

PGPC is an oxidized phospholipid that can be formed under conditions of oxidative stress. [1] It is found as a component in mildly oxidized LDL (MM-LDL) and in products formed from the oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (Ox-PAPC). [2] PGPC activates peroxisome proliferator-activated receptor (PPARα) in a concentration-dependent manner in a cell-based ligand-binding assay. [3] It increases VCAM1 and E-selectin expression in human aortic endothelial cells (HAECs), as well as HAEC binding by monocytes and polymorphonuclear neutrophils (PMNs), in a concentration-dependent manner.[4] PGPC (37.5 μM) also increases total 5-lipoxygenase metabolites in murine resident peritoneal macrophages (RPMs) and induces apoptosis in A7r5 rat aortic smooth muscle cells in vitro when used at a concentration of 50 μM.[5][6] PGPC levels are increased in the serum, LDL, and peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease. [7] UVA irradiation increases PGPC levels in cultured human skin fibroblasts. [8]

Cas No.

89947-79-5

分子式

C29H56NO10P

分子量

609.738

别名

1-Palmitoyl-2-glutaryl phosphatidylcholine

储存和溶解度

Ethanol:20 mg/mL
DMSO:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years