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Dabuzalgron
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dabuzalgron图片
CAS NO:219311-44-1
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
达布扎琼
Ro 115-1240
产品介绍
Dabuzalgron 是一种口服活性选择性 α-1A 肾上腺素受体激动剂,用于治疗尿失禁。它通过维持线粒体功能来预防多柔比星引起的心脏毒性。

产品描述

Dabuzalgron is an orally active selective alpha-1A adrenergic receptor agonist used to treat urinary incontinence. Dabuzaron prevents cardiotoxicity caused by doxorubicin by maintaining mitochondrial function.

体外活性

Dabuzaron treatment increased ERK phosphorylation in a dose-dependent manner with an EC50 of 4.8 μM. ERK1 / 2 activation helps Dabuzaron's cardioprotection. Dabuzaron (10 μM; 4 hours) protects NRVM from cell death caused by doxorubicin (DOX). Dabuzaren (10 μM; 4 hours) activation of α1A-AR alleviates the harmful effects of DOX on mitochondrial membrane potential and eliminates the activation of important elements of the apoptotic response to mitochondrial damage.

体内活性

Dabuzaron (10μg / kg; oral tube; twice daily; 7 consecutive days; C57B16J wild-type or α1A-AR gene knockout mice) treatment can prevent DOX cardiotoxicity by activating α1A-AR. Dabuzaron prevents mitochondrial function-related transcript reduction, up-regulates PGC1α, retains ATP content, and reduces oxidative stress in DOX-treated mouse hearts.

Cas No.

219311-44-1

分子式

C12H16ClN3O3S

分子量

317.79

别名

达布扎琼;Ro 115-1240

储存和溶解度

DMSO:25 mg/mL(78.67 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years