MS-073 (CP-162398) is a P-glycoprotein inhibitor (P-gp). The in vitro resistance to vincristine (VCR) was almost completely reversed in VCR-resistant P388 cells, and the resistance of VCR, adriamycin (ADM), etoposide, and actinomycin D in ADM-resistant human myeloid leukemia K562 (K562/ADM) cells in vitro was also reversed. MS-073 reverses MDR by competitively inhibiting the binding of drugs to P-glycoprotein.

129716-45-6

C31H33N3O2

479.61

CP-162398;MS 073;CP162398;CP 162398

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years