Oxolinic acid 是一种抗生素，对革兰氏阴性菌和革兰氏阳性菌均有效，可研究急性和慢性尿路感染。它是一种 DNA/RNA 合成抑制剂，也是一种多巴胺摄取抑制剂，能刺激小鼠的活跃过度。

Oxolinic acid is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.

Oxolinic acid, a quinolone antibacterial agent, inhibits reversibly the ATP-dependent replicative DNA synthesis in permeable cell systems as well as in cellophane disk lysates[4]. It also inhibits bacterial DNA gyrase but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 μg/ml[5][6][7].

The antimicrobial agent oxolinic acid, injected i.p. in mice, induces a dose dependent increase in locomotor activity. the stimulant locomotor effect of oxolinic acid depends on the blockade of the neuronal dopamine uptake complex[2].

14698-29-4

C13H11NO5

261.233

恶喹酸;Nidantin;Dioxacin;Urinox;Emyrenil;NSC 110364

DMSO:2.5 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years