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Azlocillin sodium salt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Azlocillin sodium salt图片
CAS NO:37091-65-9
包装与价格:
包装价格(元)
500 mg电议
1 g电议
1 mL*10 mM(in DMSO)电议

产品名称
阿洛西林钠
Azlocillin sodium
Sodium azlocillin
产品介绍
Azlocillin sodium 是一种半合成青霉素,是内酰胺类广谱抗生素。它具有抗假单胞杆菌的活性,并对抗寄生虫Plasmodium falciparum有效。

产品描述

Azlocillin, an acylampicillin, is a broad-spectrum antibiotics

体外活性

Azlocillin (12.5 μg/mL) inhibits over 75% of the isolates of Pseudomonas aeruginosa. Azlocillin (12.5 μg/mL) is also active against indole-negative and -positive Proteus spp., inhibiting 98 and 71%, respectively. Azlocillin is more active than mezlocillin, ticarcillin, and carbenicillin and as active as BLP-1654 against isolates of P. aeruginosa. [1] The acyl side chains of Azlocillin have an ureido-(urea) structurehence the name "ureidopenicillins" or, more specifically, "acylureidopenicillins." In vitro studies against P. aeruginosa demonstrates that piperacillin has activity that is twice that of azlocillin, 4 times that of mezlocillin and ticarcillin, and about 8 times that of carbenicillin. Azlocillin produces elongated bacterial forms with delayed or no lysis in morphologic studies. [2] Azlocillin has MICs of 12.5 μg/mL on Pseudomonas aeruginosa. Azlocillin (3.125 μg/mL) results in a reduction in the rate of growth but no bactericidal phase on Pseudomonas aeruginosa. Azlocillin decreases an initial lag phase with increasing drug concentration. At the lower concentration of tobramycin (0.5 μg/ml), the combinations with both the high and the low concentrations of Azlocillin are more effective than the individual components on Pseudomonas aeruginosa. [3] Isolates with derepression of AmpC enzyme are one to two doubling dilutions more resistant to azlocillin than are those in which increased efflux or impermeability is inferred. Those with secondary β-lactamases are mostly (12/14 cases) susceptible to ceftazidime at 4 mg/L, but are amongst the most resistant to Azlocillin (MIC ≥128 mg/L in 10/14 cases). [4]

Cas No.

37091-65-9

分子式

C20H22N5NaO6S

分子量

483.47

别名

阿洛西林钠;Azlocillin sodium;Sodium azlocillin

储存和溶解度

H2O:89 mg/mL (184.1 mM)
DMSO:90 mg/mL (186.2 mM)
Ethanol:3 mg/mL (6.19 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years