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CH-0793076
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CH-0793076图片
CAS NO:534605-78-2
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品名称
TP3076
产品介绍

产品描述

CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein). CH-0793076 inhibits DNA topoisomerase I (IC50: 2.3 μM).

体外活性

CH0793076 (6 days at 37°C) displays antiproliferative activity against PC-6/BCRP and PC-6/pRC cells (IC50: 0.35 and 0.18 nM).

体内活性

TP300 (1-100 mg/kg; bolus intravenous injection once per week for 3 weeks, for a total of three doses) shows more than 50% of tumor growth inhibition in all nine models.

Cas No.

534605-78-2

分子式

C26H26N4O4

分子量

458.51

别名

TP3076

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years