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D-erythro/L-threo Lysosphingomyelin(d18:1)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
D-erythro/L-threo Lysosphingomyelin(d18:1)图片
CAS NO:82970-80-7
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议

产品名称
D-erythro/L-threo Lysosphingomyelin (d18:1)
产品介绍

产品描述

Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50= ~35 nM).4Levels of D-erythrolysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B.2,5L-threolysosphingomyelin is also an S1P1-3agonist (EC50s = 19.3, 131.8, and 313.3 nM, respectively).3This product is a mixture of D-erythroand L-threolysosphingomyelin.

Cas No.

82970-80-7

分子式

C23H49N2O5P

分子量

464.62

别名

D-erythro/L-threo Lysosphingomyelin (d18:1)

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years