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SF1126
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SF1126图片
CAS NO:936487-67-1
包装:5 mg
市场价:7000元

产品介绍

产品描述

SF1126 is a relevant pan and dual first-in-class PI3K/BRD4 inhibitor. SF1126 is an RGDS-conjugated LY294002 prodrug, which is designed to exhibit increased solubility and bind to specific integrins within the tumor compartment.

体外活性

SF1126 (0.5-2.5 μM; pre-30 minutes) and sorafenib shows that combined treatment of SF1126 and sorafenib blocks multiple key enzymes in PI3K/AKT/mTOR and Ras/Raf/MAPK pathway. SF1126 (1-10 μM; 24 hours) causes cell-cycle arrest with a proportional increase in G0-G1 and a decrease in the number of cells in the S-phase in Hep 3B, Hep G2, SK-Hep1, and Huh7 cells. SF1126 (0-6 μM; 48 hours) inhibits Hep3B, HepG2, SK-Hep1, and Huh7 cell proliferation with IC50s of 5.05, 6.89, 3.14, and 2.14 μM, respectively [1].

Cas No.

936487-67-1

分子式

C39H48N8O14

分子量

852.84

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years