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UCT943
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UCT943图片
CAS NO:1450666-80-4
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
UCT943是恶性疟原虫PI4K的抑制剂(IC50 = 23 nM)。

产品描述

UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).

体外活性

UCT943 maintains a high degree of selectivity (>200-fold) for parasite PI4K versus human PI4Kβ isoenzyme (IC50 = 5.4 μM) in vitro, and its inhibition is associated with immunosuppressive effects[1].

体内活性

In vivo, UCT943 shows good efficacy in the Plasmodium vivax (3-10 mg/kg; orally) and P. falciparum NSG mouse models (0.01-10 mg/kg; orally). UCT943 (10 mg/kg; p.o.) reduces parasitemia by >99.9% in the mouse P. berghei infection model and cures all mice (MSD>30)[1].

Cas No.

1450666-80-4

分子式

C22H20F3N5O

分子量

427.42

储存和溶解度

DMSO:250 mg/mL (584.90 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years