LasR-IN-2 是一种LasR抑制剂，可与 TRY-56 残基形成氢键。LasR-IN-2 可用于细菌感染，中性粒细胞减少症、严重烧伤和囊性纤维化 (CF) 慢性肺病的研究。

LasR-IN-2 is a LasR inhibitor that forms H-bonding with TRY-56 residue. LasR-IN-2 can be used in the research of bacterial infection, neutropenia, severe burns and chronic lung disease in cystic fibrosis (CF) [1].

LasR-IN-2 (Compound 8a, 4.68-150 μg/mL, 24 h) inhibits P. aeruginosa growth [1]. LasR-IN-2 (18.5 μM, 24 h) inhibits biofilm formation, pyocyanin production, and rhamnolipids production [1]. LasR-IN-2 (24 h) inhibits human dermal fibroblasts (HDFa) growth with an IC 50 value of 102 μM [1]. Cell Viability Assay [1] Cell Line: P. aeruginosa (ATCC27853) Concentration: 4.68-150 μg/mL Incubation Time: 24 h Result: Inhibited bacterial growth with a MIC value of 74.40 μM.

C21H16ClN3O2

377.82

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years