IBR2 是一种特异性的RAD51抑制剂，可抑制RAD51介导的 DNA 双链断裂修复。它破坏RAD51的多聚化，加速蛋白酶体介导的RAD51蛋白质降解，抑制癌细胞的生长并诱导细胞凋亡。

IBR2 is a potent and specific RAD51 inhibitor that inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth, and induces apoptosis.

IBR2 can inhibit the growth of triple-negative human breast cancer cell line MBA-MD-468 with IC50 of 14.8 μM. IBR2 shows interesting RAD51 inhibition activities.?RAD51 is rapidly degraded in IBR2-treated cancer cells, and the homologous recombination repair is impaired, subsequently leading to cell death.?The IC50 values of the original IBR2 are in the range of 12-20 μM for most tested cancer cell lines[1].

313526-24-8

C24H20N2O2S

400.49

Isoquinoline

DMSO:100 mg/mL (249.69 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years