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Pyridostatin Trihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pyridostatin Trihydrochloride图片
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
RR-82 Trihydrochloride
Pyridostatin Trihydrochloride(free base 1085412-37-8 )
产品介绍
Pyridostatin Trihydrochloride 是一种 G-四链体稳定剂,Kd 为 490 nM。

产品描述

Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM.

体外活性

Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes

细胞实验

Cells are plated at equal confluence and either untreated or treated with 2 μM Pyridostatin continually for 72 h. Cells from individual plates are trypsinized and counted in a Coultercounter. Graphs represent total cell numbers at each time interval and error bars represent S.E.M. Data represent three independent experiments.

Cas No.

T4457

分子式

C31H35Cl3N8O5

分子量

706.02

别名

RR-82 Trihydrochloride;Pyridostatin Trihydrochloride(free base 1085412-37-8 )

储存和溶解度

DMSO:10mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years