SR 11302 是一种类视黄醇,是一种激活蛋白-1 转录因子抑制剂,能够特异性抑制 AP-1 活性,而不会激活视黄酸反应元件 (RARE) 的转录。
产品描述
SR 11302 is an inhibitor of activator protein-1 (AP-1).
体外活性
SR 11302 can inhibit the growth of breast cancer cell line T-47D, the lung cancer line Calu-6, and HeLa cells. SR 11302 had very little effect on either the proliferation or the differentiation of HL-60, fresh APL, and NB4 cells[2].
体内活性
In an AP-1-luciferase transgenic mouse carcinogenesis model, SR11302 significantly inhibits both AP-1 activations in 7,12-dimethyl benz(a)anthracene-initiated mouse skin and 12-O-tetradecanoylphorbol-13-acetate-induced papilloma formation[3].
Cas No.
160162-42-5
分子式
C26H32O2
分子量
376.53
储存和溶解度
DMSO:50 mg/Ml(132.79 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years