A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM[1]. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection[2].

A2ti-2 (compound 7a) is an annexin A2-S100A10 protein-protein interaction blocker[1]. A2ti-2 is less effective with<50% reduction in HPV16 PsV infection achieved at 100 μM. A2ti-1 decreases HPV16 entry with a 20% reduction at 100 μM[2].

482646-13-9

C18H18N4O2S

354.43

A2ti-2

DMSO:250 mg/mL (705.36 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years