JNJ-37822681 是一种新型的、高选择性的多巴胺 D2 受体拮抗剂，其特点是与多巴胺 D2 受体的快速解离速率。

JNJ-37822681 is a novel, highly selective dopamine D2 receptor antagonist characterized by a rapid dissociation rate from the dopamine D2 receptor.

JNJ-37822681 occupied D2 receptors in rat brain at relatively low doses (ED50 = 0.39 mg/kg) and was effective in animal models of psychosis (e.g., inhibition of apomorphine-induced stereotypy or D-amphetamine/phencyclidine-induced hyperlocomotion)[4].

935776-74-2

C17H17F5N4

372.34

JNJ 37822681;JNJ37822681

DMSO:55 mg/ml (147.71 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years