JNJ-37822681 dihydrochloride 是特异性的、有中枢活性的，可快速解离的多巴胺 D2受体拮抗剂，与多巴胺 D2L受体结合的亲和力适中 (Ki=158 nM)。JNJ-37822681 dihydrochloride在精神分裂症和躁郁症领域有研究价值。

JNJ-37822681 dihydrochloride is a novel, highly selective dopamine D2 receptor antagonist characterized by a rapid dissociation rate from the dopamine D2 receptor. JNJ-37822681 dihydrochloride shows a moderate binding affinity for the dopamine D2L receptor with a Ki of 158 nM.

JNJ-37822681 dihydrochloride occupied D2 receptors in rat brain at relatively low doses (ED50 = 0.39 mg/kg) and was effective in animal models of psychosis (e.g., inhibition of apomorphine-induced stereotypy or D-amphetamine/phencyclidine-induced hyperlocomotion)[4].

2108806-02-4

C17H19Cl2F5N4

445.26

DMSO:33.33 mg/mL (74.86 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years