HDAC8-IN-2 (compound 5o) 是一种有效的HDAC8抑制剂, 对smHDAC8(曼氏血吸虫组蛋白去乙酰化酶 8) 和hHDAC8的IC50值分别为 0.27 和 0.32 μM。HDAC8-IN-2 对血吸虫幼虫有显著杀灭作用。HDAC8-IN-2 对成虫产卵有显著影响。

HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC 50 values of 0.27 and 0.32 μM for smHDAC8 ( Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. HDAC8-IN-2 shows significant killing of the schistosome larvae. HDAC8-IN-2 markedly impairs egg laying of adult worm pairs [1].

C21H16N2O5

376.36

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years