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SW-100
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SW-100图片
CAS NO:2126744-35-0
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
SW-100 是一种选择性组蛋白去乙酰化酶 6 抑制剂,IC50为2.3 nM。它有提高的穿过血脑屏障的能力,相对于其他 HDAC 同工酶,还显示出对 HDAC6 的至少高 1000 倍的选择性。

产品描述

SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the blood-brain-barrier.

体外活性

SW-100 (0.01-10 μM; 48 hours) shows obvious enhance in the acetylated α-tubulin levels in a dose-dependent manner [1].

体内活性

In mouse model of Fragile X syndrome, SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing [1].

Cas No.

2126744-35-0

分子式

C17H17ClN2O2

分子量

316.78

别名

SW-100

储存和溶解度

DMSO:125 mg/mL (394.60 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years