您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > CU-32
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CU-32
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CU-32图片
CAS NO:2400954-16-5
包装:25 mg
市场价:9493元

产品介绍

产品描述

CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM.

Cas No.

2400954-16-5

分子式

C11H10IN5O2

分子量

371.13

储存和溶解度

DMF:30 mg/mL
DMSO:PBS (pH 7.2) (1:5):0.16 mg/mL
DMSO:30 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years