2-Pyridinecarboxamide, 4-[[6-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]iminomethyl]amino]-3-pyridinyl]oxy]-N-methyl-是一种新的芳基胍抑制剂。

2-Pyridinecarboxamide, 4-[[6-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]iminomethyl]amino]-3-pyridinyl]oxy]-N-methyl- is a novel aryl-guanidino inhibitor.

Jurkat and HUT78 cells was markedly inhibited by DCZ3301 treatment in a time- and dose- dependent manner, IC50 values for Jurkat and HUT78 cells were 3.02 μM and 9.42 μM, respectively, after 2-Pyridinecarboxamide, 4-[[6-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]iminomethyl]amino]-3-pyridinyl]oxy]-N-methyl- treatment for 48 h.

2136278-38-9

C20H16ClF3N6O2

464.83

NPS ALX Compound 4a hydrochloride(1:1)(299433-10-6 Free base);2-Pyridinecarboxamide, 4-[[6-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]iminomethyl]amino]-3-pyridinyl]oxy]-N-methyl-

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years