Gemcabene 是一种具有抗炎活性的降脂剂。 Gemcabene 降低低密度脂蛋白胆固醇和甘油三酯，提高高密度脂蛋白胆固醇，并降低促炎急性期蛋白、C 反应蛋白。

Gemcabene is a lipid-lowering agent with anti-inflammatory activity. Gemcabene lowers low-density lipoprotein cholesterol and triglycerides, raises high-density lipoprotein cholesterol, and decreases pro-inflammatory acute-phase protein, C-reactive protei

Gemcabene significantly downregulates hepatic mRNA markers of inflammation including TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB, lipogenesis, fibrosis including TIMP-1 and MMP-2, and lipid modulation including ApoC-III, ACC1, ADH-4 and Sulf-2[2].

183293-82-5

C16H30O5

302.41

PD-72953;Gemcabene

DMSO:125 mg/mL (413.35 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years