DHFR-IN-1 (compound 12) 是一种有效的选择性DHFR(二氢叶酸还原酶)抑制剂，其IC50为 40.71 nM。 DHFR-IN-1 对革兰氏阳性菌和革兰氏阴性菌具有良好的抗菌活性。DHFR-IN-1 具有一定的抗真菌活性。DHFR-IN-1 与 Levofloxacin 具有较高的协同效应，其 FIC (部分抑菌浓度指数)值为 0.249。

DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC 50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin, where the FIC (fractional inhibitory concentration index) value is 0.249 [1].

2757991-65-2

C22H22N6O4S2

498.58

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years