SUVN-911 是高选择性的，大脑通透性的和口服有效的神经元烟碱乙酰胆碱 α4β2 受体拮抗剂，Ki为 1.5 nM。SUVN-911显示出抗抑郁作用。

suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.

suvn-911 shows good selectivity against over 70 receptors which includes GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors, and prostaglandins. suvn-911 displays high selectivity for α4β2 over α3β4 nAChR[2].

In male Wistar rats, suvn-911 (1.0-10.0 mg/kg; p.o.) showed significant antidepressant-like activity with no signs of tachyphylaxis. suvn-911 (3 mg/kg; p.o.) showed high oral exposures, longer half-lives(T1/2 = 3.34 hr), and adequate brain penetration in Wistar rats. suvn-911 showed metabolic stability and no cardiovascular and gastrointestinal side effects[1].

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suvn-911

DMSO:125 mg/mL (478.65 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years