A 582941 HCl (848591-90-2(free base)) 是一种具有广谱认知增强特性的 alpha7 神经元烟碱受体激动剂。

A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties

A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.?A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function[1].

T8725

C17H21ClN4

316.83

A 582941 HCl (848591-90-2(free base))

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years