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Cefuroxime sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cefuroxime sodium图片
CAS NO:56238-63-2
包装与价格:
包装价格(元)
500 mg电议
1 g电议
1 mL*10 mM(in DMSO)电议

产品名称
Anaptivan
头孢呋辛钠
Cefuroxime sodium salt
Biociclin
产品介绍
Cefuroxime sodium 是一种具有口服活性的头孢菌素抗生素,增加了对 β-内酰胺酶的稳定性。

产品描述

Cefuroxime Sodium is the sodium salt form of cefuroxime and a semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic with bactericidal activity. Cefuroxime sodium inhibits bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. Lack of cross-linking results in a reduction of cell wall stability and leads to cell lysis.

体内活性

The intravenous LD50 of cefuroxime sodium for mice is 10.4 g/kg. The maximum dosage administered in other acute toxicity tests is well tolerated by mice (10 g/kg, subcutaneous), by rats (4 g/kg, intravenous, 5 g/kg, subcutaneous) and by cats, dogs and monkeys (2 g/kg, intramuscularly). However, when cefuroxime sodium is administered subcutaneously (s.c.) or intramuscularly (i.m.) for 3 months to rats (100, 300 or 900 mg/kg/day) followed by a recovery period, and also for 6 months to rats and dogs (50, 150 or 450 mg/kg/day) and for 1 month to monkeys (150 or 450 mg/kg/day), there are no serious toxic effects in all tests. In rats large doses cause some increase in urine volume and electrolyte excretion, and slightly aggravates an age related nephropathy. Administration to rats intravenously (i.v.) for 1 month of up to 400 mg/kg/day has no toxic effects. In reproduction studies on mice and rabbits there are no adverse effects on fertility, organogenesis or the rearing of young[1].

Cas No.

56238-63-2

分子式

C16H15N4NaO8S

分子量

446.37

别名

Anaptivan;头孢呋辛钠;Cefuroxime sodium salt;Biociclin;Cefuroxime sodium

储存和溶解度

Ethanol:<1 mgml
DMSO:19 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years