Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis,psoriasis and allergic dermatitis, eczema[1].

The prodrug of alclometasone is alclometasone dipropionate[2]. Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) has no effects on hepatic drug metabolism in female rats or DS strain mice[2].

67452-97-5

C22H29ClO5

408.92

7a-Chloro-16a-methyl prednisolone;Alclometasone

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years