LG100754 is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPARγ heterodimers.

LG100754 can also improve TNFα-mediated insulin resistance in mature adipocytes. LG100754 is a selective activator of endogenous RXR heterodimers. LG100754 acts as a bona fide activator of endogenous RXR: PPARγ heterodimers and regulator of insulin-dependent signaling pathways[1].

LG100754 (100 mg/kg) fully blocks the enhance in glucose levels. It also shows that LG100754 can improve insulin resistance in vivo[1].

180713-37-5

C26H36O3

396.56

UVI 2112;LG100754

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years