AA147 是小分子内质网蛋白稳态调节剂，能够选择性激活未折叠蛋白反应的ATF6臂，摘自专利文献 WO2017117430A1 中的化合物 147*。

AA147 is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially triggers ATF6 signaling through a mechanism involving localized metabolic activation and selective covalent modification of ER resident proteins that regulate ATF6 activity.

393121-74-9

C16H17NO2

255.31

ATF6-activator-147;AA147

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years