SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.

It induces NF-κB signaling in cells expressing human TLR2 (EC50= 0.55 μM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 μM. SMU127 induces the production of TNF-α in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 μM.

In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.

903864-87-9

C16H23N3O3S

337.44

SMU127

DMF:1 mg/mL
DMF:PBS (pH 7.2) (1:4):0.20 mg/mL
DMSO:Slightly soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years