Itaconate-alkyne 是一种生物正交探针，用于对炎症性巨噬细胞中的衣康酸进行定量和位点特异性化学蛋白质组学分析，并能够对其直接靶标进行生化评估和蛋白质组学分析。

Itaconate-alkyne is a bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of itaconate in inflammatory macrophages and enables biochemical evaluation and proteomic analysis of its direct targets.

Itaconate-alkyne can capture itaconate targets including DNA damage-binding protein 1 (DDB1), Gelsolin (GSN), ATP-citrate synthase (ACLY) and Adenylate kinase 2 (AK2) in inflammatory macrophages[1].

2454181-83-8

C13H18O4

238.28

ITalk;Itaconate-alkyne

DMSO:245 mg/mL (1028.20 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years