nAChR agonist 1 是一种脑渗透性和口服有效的正变构 α7 烟碱乙酰胆碱受体 (α7 nAChR) 调节剂。它在 Ca2+中，对内源性表达 α7 nAChR 的人 IMR-32 神经母细胞瘤细胞的EC50为 0.32 μM。它可用于阿尔茨海默病的研究。

nAChR agonist 1 is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.

nAChR agonist 1(compound 28) is a novel PAM of α7 nicotinic acetylcholine receptor (α7 nAChR).?Compound 28 showed good in vitro potency, with pharmacokinetic profile across species with excellent brain penetration and residence time.?Compound 28 robustly reversed the cognitive deficits in episodic/working memory in both time-delay and scopolamine-induced amnesia paradigms in the novel object and social recognition tasks, at very low dose levels.

1394371-75-5

C20H18ClNO3S2

419.95

DUN71755;nAChR agonist 1

DMSO:120mg/ml(285.76mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years