C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids. It increases the amount delivered and toxicity of doxorubicin in cancerous but not non-cancerous cells when incorporated into the nanoliposomal membrane of nanoliposomal-doxorubicin. C8 Galactosylceramide induces proliferation and cytokine production by splenocytes in vitro at concentrations ranging from 100-1,000 ng/ml but has no effect on natural killer T cell production in vivo. It also activates NF-κB production in C6 glioma cells when used at a concentration of 10 μM.

41613-16-5

C32H61NO8

587.83

C8 Galactosylceramide (d18:1/8:0);C8 Galactosylceramide (d18:1/8:0)

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years