IMM-H007 是一种新型降脂剂，可增加 abca1 蛋白的表达。

IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression

IMM-H007 (H007) significantly inhibits monocyte adhesion to endothelial cells and its transendothelial migration.?Mechanistically, H007 markedly represses TNFα-induced IκBα degradation and NF-κB nuclear translocation, therefore leading to NF-κB-mediated inflammatory suppression.?Moreover, another inflammatory signaling JNK/c-Jun, which is always co-activated with NF-κB in response to pro-inflammatory stimuli, is also found to be restrained by H007 through reducing its phosphorylation status.?H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling.

1221412-23-2

C18H19N5O4

369.381

IMM-H007

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years