Manganese(salen) chloride 是超氧化物歧化酶和过氧化氢酶的一种模拟物，具有氧自由基清除性能。它可减轻内毒素血症猪的急性肺损伤。

Manganese(salen) chloride (EUK-8) is a superoxide dismutase and catalase mimetic. Manganese(salen) chloride (EUK-8) is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine.

Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity that also completely blocks β-AP-induced free radical accumulation and lipid peroxidation [2].

Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant [3] . Animal Model: Wild-type (WT) and harlequin (Hq) B6CBA male and female mice [3] Dosage: 25 mg/kg/day Administration: I.p. 3 times a week for 4 weeks Result: Prevented myocardial oxidant damage provoked by biomechanical stress. Improved survival following biomechanical stress. Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis. Furthermore, because antioxidant treatment protected both the oxidative stress-prone Hq mouse model and WT mice against pressure overload-induced maladaptive left ventricular remodeling and cardiac decompensation, it may be useful as a novel therapeutic tool in the treatment of human heart failure.

53177-12-1

C16H14ClMnN2O2

356.69

EUK-8;Manganese(salen) chloride

DMSO:8.33 mg/mL (23.35 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years