cis-4-Hydroxy-L-proline 是脯氨酸的一种类似物,抑制胶原蛋白的产生。它通过阻止三层螺旋胶原在细胞层上的沉积从而抑制成纤维细胞的生长。它还可抑制原发性N-亚硝基甲基脲诱导的大鼠乳腺肿瘤的生长。
产品描述
cis-4-Hydroxy-L-proline is an inhibitor of the synthesis and extracellular deposition of collagen. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer.
体内活性
cis-4-Hydroxy-L-proline depressed the growth of primary N-nitrosomethylurea-induced rat mammary tumors[4].
Cas No.
618-27-9
分子式
C5H9NO3
分子量
131.13
别名
cis-4-Hydroxy-L-proline
储存和溶解度
H2O:100 mg/mL (762.60 mM)
DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years