IM-156 is an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase (IC50= 2.2 μM) and an activator of AMP-activated protein kinase α (AMPKα).1,2It reduces the oxygen consumption rate (OCR; IC50= 3.3 μM) and decreases mitochondrial ATP production in Eμ-Mycmouse lymphoma cells.1IM-156 (10, 30, and 50 μM) increases AMPKα activity in primary rat peritoneal mesothelial cells and protects against chlorhexidine-induced peritoneal fibrosis in rats when administered at a dose of 1 mg/kg.2It reduces tumor growth in an AT-84 murine oral cancer model and decreases age-related decline in novel object recognition, spatial working, and contextual memory in mice.3,4

2043654-54-0

C13H16F3N5O·XC2H4O2

315.3

IM-156 (acetate)

DMF:1 mg/mL
DMSO:1 mg/mL
Ethanol:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years